The regular spice of the kitchen is a potential applicant for the creation of a medicine against Coronavirus by a team of Indian scientists.
Dhanbad has found that Piperine, found in black pepper, can connect and inhibit the SARS-Cov-2 viruse that causes the disease, a computer analysis carried out by Physics researchers at the Indian Institute of Technology (Indian School of Mines).
Professor Umakanta Tripathy,the team leader who explained their work, said that coronavirus, like any other virus, uses surface proteins to reach the human corporal cells. He and his team searched for natural compounds that could link them and prevent the virus from breaking into human cells. They used advanced computer-based methods including molecular docking and simulation of molecular dynamics to track down possible inhibitors.
They chose 30 molecules in common spices from the kitchen and explored their therapeutic function. Piperine has become a heavy banner of the virus proteins and is an alkaloid found in pepper responsible for its pungent nature.
Professor Tripathy spoke to Indian Science Wire: “We have a very promising performance. There should be no doubt that the research is solely computational and needs additional verification in laboratories. It’s still a significant lead, though.”
Professor Tripathy’s Ph.D. students – Janmejaya Rout and Bikash Chandra Swain were part of the team. They released a paper on their work on “Silico research on spice molectules as a potent inhibitor of SARS-CoV-2” in the Journal on Biomolecular Structure and Dynamics.
In India and globally over one million people died as a result of the Covid 19 pandemic. Scientists worldwide are working together to create therapeutic medicines to treat SARS-CoV-2 affected patients. In various parts of the world, including India, some vaccine candidates are also tested.
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